对炼测试的压缩血压反应的性别差异:现实世界的临床分析
Shengming Li1, Tianjing Zhang2, Jia He2
1Cardiac Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.
Journal of human hypertension
|June 30, 2025
概括
在对运动的过度缩血压反应 (ESBPR) 中,性别差异很大. 年龄对女性和男性的ESBPR的影响不同,绝经后女性的患病率更高.
科学领域:
- 心脏病学 心脏病学
- 运动生理学 运动生理学
- 临床研究 临床研究
背景情况:
- 目前美国心脏协会对缩性血压对运动反应 (ESBPR) 的指导方针使用了特定于性别的值.
- 这些门主要来自年轻,健康的人群,这引发了对其在各种临床环境中的适用性问题的质疑.
- 了解缩血压 (SBP) 运动期间反应的性别特异性差异对于准确的临床评估至关重要.
研究的目的:
- 为了研究与年龄相关的SBP对运动反应模式的性别差异.
- 评估当前ESBPR值在不同年龄组和性别的临床适用性.
- 为了确定性别是否会改变年龄和ESBPR之间的关系.
主要方法:
- 一项涉及44418名成年人 (40.6%是女性,平均年龄为49) 的横截面研究,他们接受了跑步机运动测试.
- 定义ESBPR为峰值SBP≥210mmHg的男性和≥190mmHg的女性.
- 用性别分层的多变量回归模型来分析SBP反应中的与年龄相关的模式.
主要成果:
- 在女性 (10.1%) 中,ESBPR的流行率是男性 (1.9%) 的五倍以上.
- 随着年龄的增长,男性和女性之间的SBP应答差距缩小,从年轻人中>12 mmHg到老年人中<4 mmHg.
- 年龄是女性ESBPR的重要预测因素,特别是绝经后的女性 (年龄≥51岁),但不是男性.
结论:
- 女性和男性在SBP对运动的反应中表现出明显的与年龄相关的模式.
- 目前女性的ESBPR较低值可能导致绝经后妇女过分分类异常.
- 临床指南可能需要重新评估,以考虑运动诱导的SBP反应的性别和年龄特定变化.
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