使用人工神经网络,对使用者一致的过渡路径进行代变化学习
Alberto Megías1,2, Sergio Contreras Arredondo1, Cheng Giuseppe Chen1
1Laboratoire International Associé Centre National de la Recherche Scientifique et University of Illinois at Urbana-Champaign, Unité Mixte de Recherche 7019, Université de Lorraine, Lorraine, France.
本研究介绍了一种新的神经网络策略,用于绘制复杂系统中罕见事件过渡途径的地图. 该方法同时学习了提交函数及其一致的字符串,对生物分子转换产生了前所未有的洞察力.
科学领域:
- 计算化学是一种计算化学.
- 生物物理学的生物物理.
- 统计力学就是统计力学.
背景情况:
- 在复杂系统中研究罕见事件和过渡途径具有挑战性.
- 现有的方法通常依赖于近似值,这限制了它们的适用性.
研究的目的:
- 开发一种基于神经网络的新策略,以发现具有物理意义和与犯人一致的过渡途径.
- 为复杂系统中的过渡过程提供了前所未有的视角.
主要方法:
- 一个神经网络策略,同时学习提交器函数及其相关的提交器一致字符串.
- 在各种动态模式中利用犯人时间相关函数.
- 超越传统的无限小的时间延迟近似.
主要成果:
- 该方法成功地重现了既定的动态,速率常数和过渡机制.
- 它在复杂的生物分子转换中区分了多个相互竞争的途径.
- 在基准潜力和生物系统 (如异体化和蛋白质折叠) 上表现出稳健性.
结论:
- 这种方法为罕见事件的增强样本模拟提供了一个强大而通用的工具.
- 它为生物分子系统的复杂景观提供了宝贵的见解.
- 该方法可以适应集体变量,并且在神经架构中具有弹性.
更多相关视频
10:50Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches
Published on: June 21, 2022
10:44Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
Published on: December 7, 2021
相关概念视频
Neural Circuits
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
Indirect Motor Pathways
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
Associative Learning
Classical conditioning, also known...
Neural Regulation
Sequence Networks of Rotating Machines
Zero-sequence current induces a voltage drop across the generator's neutral impedance and other...
Propagation of Action Potentials
Neurons (nerve cells) have a resting membrane potential, with a slightly negative charge inside compared to outside. This is maintained by ion channels, such as sodium (Na+) and potassium (K+) channels, which control the flow of ions. When a stimulus, like a touch or a signal from another neuron, triggers the neuron, sodium channels open, allowing sodium ions to...
