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Updated: Sep 17, 2025

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
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A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

Published on: June 8, 2022

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斯芬戈辛同时抑制核进口,并通过结合进口素和PPP2R1A激活PP2A

Vaishali Jayashankar1, Peter Kubiniok2,3, Alison N McCracken1

  • 1Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697, USA.

The EMBO journal
|June 30, 2025
PubMed
概括

像FTY720这样的脂激活蛋白酶2A (PP2A) 并抑制进口蛋白,减少致癌的核蛋白. 这种双重行动提供了一种克服癌症治疗耐药性的新策略.

关键词:
家庭静态生长控制 家庭静态生长控制核进口 核进口 核进口蛋白质酸酶2A是一种斯芬哥斯基因是一种神.

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