Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

38.9K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
38.9K
Working Memory01:24

Working Memory

449
Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this...
449
Neuroplasticity01:01

Neuroplasticity

801
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
801
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

600
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
600
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

213
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
213
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.2K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.2K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

The genetic signature of memory encoding along the human hippocampal axis.

bioRxiv : the preprint server for biology·2026
Same author

Impact of operative time on 30-day surgical outcomes following tissue expander-based breast reconstruction.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2026
Same author

Maternal sensitivity and children's internalizing problems: the role of children's gender and social skills.

BMC psychology·2026
Same author

Functional Outcomes in Patients with Hand Burns Receiving Long-Term Occupational Hand Therapy: A Burn Unit's 10-Year Experience.

Journal of burn care & research : official publication of the American Burn Association·2026
Same author

Time-restricted feeding extends healthspan in both sexes and lifespan in male C57BL/6 J mice.

Nature aging·2026
Same author

Not all gut cellular circadian oscillators are food entrainable.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Neural timescales from a computational perspective.

Nature neuroscience·2026
Same journal

Author Correction: Spinal cord Tau pathology induces tactile deficits and cognitive impairment in Alzheimer's disease via dysregulation of CCK neurons.

Nature neuroscience·2026
Same journal

Hippocampal theta sweeps indicate goal direction during navigation.

Nature neuroscience·2026
Same journal

Just how goal-directed are hippocampal theta sweeps, anyway?

Nature neuroscience·2026
Same journal

Goal-directed hippocampal theta sweeps during memory-guided navigation.

Nature neuroscience·2026
Same journal

Connectomic evidence that ordered activity drives neuromuscular network formation.

Nature neuroscience·2026
查看所有相关文章

相关实验视频

Updated: Sep 17, 2025

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
07:03

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Published on: July 31, 2019

6.9K

人类时钟增强新皮质功能

Yuxiang Liu1,2, Miles R Fontenot1,2, Ashwinikumar Kulkarni1,2

  • 1Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX, USA.

Nature neuroscience
|June 30, 2025
PubMed
概括
此摘要是机器生成的。

转录因子CLOCK对于昼夜节律至关重要,在具有类似人类大脑表达的小鼠中显示出增强的认知灵活性. 这表明CLOCK进化了新的大脑功能,有助于人类的专业化.

更多相关视频

Orienteering as a Tool for Cognitive Research: An Implementation Guide
07:13

Orienteering as a Tool for Cognitive Research: An Implementation Guide

Published on: November 29, 2024

915
Inter-Brain Synchrony in Open-Ended Collaborative Learning: An fNIRS-Hyperscanning Study
04:44

Inter-Brain Synchrony in Open-Ended Collaborative Learning: An fNIRS-Hyperscanning Study

Published on: July 21, 2021

4.3K

相关实验视频

Last Updated: Sep 17, 2025

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
07:03

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Published on: July 31, 2019

6.9K
Orienteering as a Tool for Cognitive Research: An Implementation Guide
07:13

Orienteering as a Tool for Cognitive Research: An Implementation Guide

Published on: November 29, 2024

915
Inter-Brain Synchrony in Open-Ended Collaborative Learning: An fNIRS-Hyperscanning Study
04:44

Inter-Brain Synchrony in Open-Ended Collaborative Learning: An fNIRS-Hyperscanning Study

Published on: July 21, 2021

4.3K

科学领域:

  • 神经科学是一个神经科学.
  • 遗传学 是一个遗传学.
  • 时间生物学 时间生物学

背景情况:

  • 转录因子CLOCK对于昼夜节律至关重要.
  • 人类新皮质的时钟表达表明了超出昼夜调节的额外,专业的功能.
  • 了解钟在人类大脑中的作用是解读认知进化的关键.

研究的目的:

  • 为了研究小鼠新皮质中人类特异的CLOCK表达的功能后果.
  • 探索CLOCK在认知功能中的潜在作用背后的分子机制.
  • 为了确定改变的CLOCK表达是否影响神经元结构和连接性.

主要方法:

  • 生成一个人性化的钟表鼠标模型 (HU小鼠) 与人类皮层表达模式.
  • 在HU小鼠中进行细胞类型特定的基因组分析,以确定受影响的基因网络.
  • 在HU小鼠中评估神经元形态 (树突复杂性,脊柱密度) 和突触功能 (ePSCs).
  • 在人类诱导的多能干细胞干细胞衍生的神经元中对CLOCK淘汰的分析.

主要成果:

  • 大小小的小鼠表现出增强的认知灵活性.
  • 基因组分析显示,HU小鼠激发神经元中与树突生长和脊柱形成相关的上调基因.
  • 在HU小鼠中,刺激神经元表现出增加的树突复杂性,脊柱密度和刺激后突触电流频率.
  • 在人类iPSC衍生的神经元中,CLOCK淘汰导致了树突复杂性降低和前突触点密度降低.

结论:

  • 改变CLOCK的时空基因表达可能会赋予进化,与大脑相关的功能.
  • 时钟在人类大脑中的增强功能可能有助于人类独特的认知专业化.
  • 时钟在调节神经元结构和连接性方面发挥着重要作用,影响认知能力.