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解码肝纤维化-肝细胞癌轴:从机制到治疗机会

Anqi Lin^1,2, Minying Xiong², Bufu Tang³

¹Jiangnan University Smart Healthcare Joint Laboratory, Donghai County People's Hospital (Kangda College of Nanjing Medical University), Lianyungang, 222000, Jiangsu Province, China.

Hepatology international

|June 30, 2025

概括

本综述详细介绍了肝纤维化如何通过复杂的信号和免疫变化发展为肝细胞癌 (HCC). 了解这些机制是开发肝癌新疗法和生物标志物的关键.

科学领域:

在瘤学瘤学.
肝病学肝病学是一种肝病学.
免疫学免疫学免疫学

背景情况:

肝细胞癌 (HCC) 是全球主要的癌症,80%-90%的病例是由肝纤维化或肝硬化引起的.
从纤维化到癌症的进展是一个复杂的,多阶段的病理过程.
当代研究正在揭示这种纤维细胞-致癌连续性的机制性见解.

研究的目的:

系统地审查肝脏纤维癌发生过程中改变信号通路的机械作用.
阐明免疫微环境重塑在从肝纤维化发展为HCC的过程中的影响.

主要方法:

对生物医学数据库进行了系统的在线选.
对纤维化驱动的肝癌发生机制的相关研究进行了策划.
进行了全面的病理生理学分析.

主要成果:

关键机制包括失调的细胞因子网络,细胞外矩阵 (ECM) 改造,表观遗传变化,免疫重编程,氧化应激和线粒体功能障碍.
评估了纤维性肝癌发生的实验模型.
评估了新兴的生物标志物和基于机制的治疗目标.

结论:

本综述为推进生物标志物发现和HCC精密治疗方法的翻译研究提供了基础.
它提供了指导,用于制定机理上明智的策略,以改善肝纤维化和HCC管理的临床结果.

关键词:

肝脏的星状细胞是什么肝细胞癌是肝细胞癌.肝脏纤维化肝脏纤维化信号通道的信号通道.瘤微环境是一个微环境.

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