ARTS与血管风险因素,MCI,痴呆症和中风相关
Debra A Fleischman1,2,3, Konstantinos Arfanakis1,4,5, Sue E Leurgans1,2
1Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
概括
翻译研究中的动脉硬化风险 (ARTS) 评分可以识别有轻度认知障碍 (MCI),痴呆和中风风险的老年人. 这种脑动脉样硬化标志物在不同人群中显示出实用性.
科学领域:
- 神经学 神经学
- 血管医学 血管医学
- 老年学是一门学科.
背景情况:
- 大脑小血管疾病是认知能力下降和中风的重要原因.
- 大脑动脉样硬化是小血管疾病的关键组成部分.
- 需要体内标记物来评估动脉样硬化和相关风险.
研究的目的:
- 研究ARTS得分与发生轻度认知障碍 (MCI),痴呆和中风之间的关联.
- 在一个大型,多样化的老年人样本中描述ARTS.
- 检查与常见的血管风险因素的关联.
主要方法:
- 分析了1226名没有痴呆症的老年人.
- 研究了ARTS得分和结果 (MCI,痴呆症,中风) 之间的关联.
- 对白人,黑人和拉丁裔参与者进行了子组分析.
主要成果:
- 在组合样本中,较高的ARTS得分与MCI,痴呆和中风风险增加有显著的关联.
- 此外,ARTS得分还与高血压和吸烟等血管风险因素相关.
- 结果显示了种族和种族小组之间的差异,表明存在差异性风险.
结论:
- ARTS评分是脑动脉样硬化的有价值的体内标记.
- 在预测MCI,痴呆和中风风险方面,ARTS的实用性得到了证明.
- 对多样化的群体进行进一步的研究是有必要的,以改进风险预测.
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