达达拉菲尔5毫克对勃起和持久存储的作用 经过尿道切除前列腺后下尿道症状:一项随机对照研究
Diaa-Eldin Taha1, Hossam Nabeeh1, Khaled Magdy Zeinelabden1
1Department of Urology, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh University Hospital, El-Giesh Street, Kafrelsheikh, 33155, Egypt.
Basic and clinical andrology
|June 30, 2025
概括
经过尿道切除前列腺 (TURP) 后每天服用塔达拉菲尔 (5 mg) 显著改善勃起功能. 然而,它对 TURP 后持续存储下泌尿道症状 (LUTS) 的影响很小.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 通过尿道切除前列腺 (TURP) 可能导致下泌尿道症状 (LUTS) 和勃起功能障碍.
- 对TURP后的LUTS和勃起功能进行早期干预的评估至关重要.
研究的目的:
- 为了评估每天服用塔达拉菲尔 (5毫克) 对改善勃起功能和 TURP 后的 LUTS 的疗效.
- 为了确定早期的塔达拉菲尔给药是否会影响持续的储存 LUTS.
主要方法:
- 一个双盲,随机对照试验,涉及195名TURP后患者.
- 患者被随机分配,接受塔达拉菲尔 (每天5毫克) 或安慰剂.
- 勃起功能 (IIEF-5) 和LUTS (IPSS) 在手术后的1,3,6个月被评估.
主要成果:
- 与安慰剂 (P < 0.001) 相比,塔达拉菲尔组显示勃起功能 (IIEF-5分数) 在统计学上显著改善.
- 塔达拉菲尔和安慰剂组都显示,随着时间的推移,整体LUTS (IPSS) 的显著减少 (P < 0.001).
- 与安慰剂相比,塔达拉菲尔组的存储LUTS有统计学上显著的较大减少 (P < 0.001).
结论:
- 早期服用塔达拉菲尔 (每天5毫克) 有效地改善了TURP后的勃起功能.
- 塔达拉菲尔在减少 TURP 后持久存储 LUTS 方面显示出适度但统计学上显著的益处.
- 塔达拉菲尔可以被视为一种单疗法选择,用于管理TURP后性功能障碍和尿路症状.
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