在参加生育中心的妇女中,甲状腺功能与怀孕脂质有关
Xilin Shen1,2, Tim I M Korevaar3, Tamarra James-Todd4,5
1Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Zhejiang, 310006, China.
怀孕前的甲状腺功能,特别是总三甲状腺素 (TT3) 和总甲状腺素 (TT4),会影响怀孕期间的脂质水平,特别是高脂胆固醇. 甲状腺激素的比率也会在妊娠的第三季度影响胆固醇.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 代谢健康 代谢健康
- 甲状腺学 甲状腺学
背景情况:
- 甲状腺激素对于脂质代谢至关重要.
- 关于怀孕期间甲状腺功能和脂质失调症的数据有限.
研究的目的:
- 检查怀孕前甲状腺功能和自身免疫与怀孕脂质生物标志物之间的联系.
- 在环境和生殖健康 (EARTH) 研究中对142名女性进行了研究.
主要方法:
- 测量了怀孕前的甲状腺生物标志物 (TSH,FT4,TT4,FT3,TT3,TPOAb,TgAb).
- 评估的妊娠脂质生物标志物 (TG,TC,HDL,非HDL,LDL).
- 使用调整的线性回归模型.
主要成果:
- 怀孕前TT3和TT4与怀孕期间的HDL胆固醇之间发现了负相关性,在孕期第三季度更强.
- 妊娠前期增加的fT3:fT4比率与高的TC,非HDL和LDL胆固醇在第三个三个月.
结论:
- 怀孕前的甲状腺功能生物标志物与怀孕脂质水平有关.
- 突出了怀孕期间孕产前甲状腺健康对孕产妇脂质概况的重要性.
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