在辅助生殖技术怀孕和自然怀孕之间对婴儿生长的比较研究
Anni Chen1, Dongyang Wang1, Yuyu Zhang1
1Department of Epidemiology and Medical Statistics, School of Public Health, Nantong University, Nantong, Jiangsu, China.
Acta obstetricia et gynecologica Scandinavica
|July 1, 2025
概括
与自然妊娠 (NP) 婴儿相比,辅助生殖技术 (ART) 婴儿在第一年表现出更快的增长. 然而,ART可能不会影响整体产后生长轨迹,这表明仔细监测仍然至关重要.
科学领域:
- 生殖医学 生殖医学
- 儿科 儿科 儿科
- 新生儿科学 新生儿科学
背景情况:
- 在全球范围内,辅助生殖技术 (ART) 的使用正在增加,目前已有超过1000万名ART婴儿出生.
- 辅助妊娠与增加妊娠和分娩不良结果的风险有关.
- 在婴儿生命的第一年,ART对婴儿生长的影响仍然是争论的主题.
研究的目的:
- 为了比较ART和自然妊娠 (NP) 婴儿之间的怀孕和分娩结果.
- 分析婴儿在生命的前12个月的生长率.
- 研究ART与婴儿快速生长之间的关联.
主要方法:
- 分析了中国南通的出生记录 (2020年1月 - 2021年6月).
- 婴儿被分为ART和NP组.
- 使用LMS方法评估婴儿生长,并使用通用估计方程 (GEE) 模型分析快速生长.
主要成果:
- 在ART婴儿中,早产和剖腹产的发病率较高.
- 单胎婴儿的整体生长速度更快,长度和体重快速增长的发病率更高.
- 多变量GEE分析证实ART与快速增长的增加有关 (OR=1.415长度,OR=1.236体重).
结论:
- 单独生育的ART婴儿在第一年更有可能经历快速增长.
- 尽管增长迅速,ART婴儿的成长轨迹与NP婴儿相似.
- ART可能不会显著影响长期的产后生长,强调需要量身定制的监测.
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