从结肠直肠癌查中获得最大的益处:从年轻开始,提供选择,找到先进的癌前病变
概括
结肠直肠癌查至关重要. 推将查年龄降低至45岁,因为早期结直肠癌发病率和死亡率上升,对资源丰富的国家建议这样做.
科学领域:
- 预防医学 预防医学
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 结肠直肠癌 (CRC) 查显著降低了符合条件人群的死亡率.
- 在年龄分别在50岁和55岁以下的人群中,观察到早期CRC发病率和死亡率增加的令人担忧的趋势.
- 这种人口变化需要重新评估目前的查指南.
研究的目的:
- 为解决早期结直肠癌发病率上升的问题提供指导.
- 为选择具有成本效益的查测试提供信息,以最大限度地扩大人口的覆盖范围.
- 根据不断变化的流行病学模式,优化CRC查策略.
主要方法:
- 分析不同年龄组结直肠癌发病率和死亡率的趋势.
- 评估各种查方式的成本效益和影响力.
- 审查支持调整查年龄和测试选择的证据.
主要成果:
- 大肠直肠癌的发病率在年轻人群 (50岁以下) 中正在增加.
- 这种发病率的增加与55岁以下人群的死亡率增加有关.
- 建议包括在资源丰富的国家将查年龄降至45岁.
结论:
- 在资源丰富的国家,对结肠直肠癌的查应该提前到45岁,因为这些国家的发病率正在上升.
- 多样化的查选择列表,优先考虑具有高级病变高灵敏度的非侵入性测试,至关重要.
- 将负担得起的,可接受的查测试与随访结肠镜进行整合是预防CRC死亡的关键.
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