儿科肝移植后的慢性疼痛:一个单中心前性观察性研究
Kaoru Tsuboi1, Hajime Uchida2, Norihiko Tsuboi1
1Department of Critical Care and Anesthesia, National Center for Child Health and Development, Tokyo, Japan.
Pediatric transplantation
|July 1, 2025
概括
慢性术后疼痛 (CPSP) 在儿科肝移植接受者中不常见,影响5.0%的患者. 女性性别是与发展CPSP相关的唯一因素,突出了长期监测的必要性.
科学领域:
- 儿科手术 儿科手术
- 移植医学 移植医学
- 疼痛管理 疼痛管理
背景情况:
- 慢性手术后疼痛 (CPSP) 影响了约20%的手术后儿童,影响了他们的生活质量.
- 关于儿科肝移植患者中CPSP患病率的数据有限.
研究的目的:
- 为了确定儿科肝移植接受者中CPSP的患病率.
- 在这个人群中确定与CPSP相关的因素.
主要方法:
- 一组242名儿科肝移植接受者 (年龄>6岁,移植后>3个月) 填写了关于疼痛的问卷.
- CPSP被定义为手术后3个月以上的疼痛,视觉模拟尺度 (VAS) ≥3.3.
- 使用多变量分析来确定相关因素.
主要成果:
- CPSP的患病率为5.0% (12/242名患者).
- 女性性别是唯一独立与CPSP相关的因素 (OR=2.91).
- 两名患者报告说日常活动受到干扰;CPSP患者的疼痛强度 (VAS) 为4.4.
结论:
- 在儿科肝移植接受者中,CPSP的患病率较低,但报告不足可能.
- 一些患者在移植后多年经历持续性疼痛,需要长期的随访.
- 识别有风险的个体,如女性,对于有针对性的干预至关重要.
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