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Updated: Sep 17, 2025

Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms
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Published on: January 25, 2018

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对神经调节素-1和E-卡德林的γ-分泌酶介导的内蛋白分解

Shweta R Malvankar1, Michael S Wolfe1

  • 1Department of Medicinal Chemistry, School of Pharmacy, The University of Kansas, Lawrence, Kansas 66045, United States.

Biochemistry
|July 1, 2025
PubMed
概括

玛分泌酶在跨膜领域内切割基质. 这项研究证实了对神经调节素1和E-cadherin在P2'处的氨不耐受规则,澄清了分裂部位,并支持了对玛分泌酶基质的一般规则.

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