用新辅助化疗和术后辅助化疗治疗的胸腔食道状细胞癌患者之间的复发模式的比较
Kunhan Ni1,2, Yixuan Huang2, Simiao Lu2
1Department of Thoracic Surgery, the Affiliated Hospital of Southwest Medical University, Sichuan, Luzhou, China.
Frontiers in oncology
|July 1, 2025
概括
辅助化疗放射治疗 (ACRT) 与新辅助化疗放射治疗 (NCRT) 相比,食道状细胞癌 (ESCC) 的复发率较低,存活率更好. 2年内早期复发显著影响ESCC患者的生存预后.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 胃肠病学 胃肠病学
背景情况:
- 食道状细胞癌 (ESCC) 是全球癌症死亡的重要原因之一.
- 局部发达ESCC的治疗策略通常涉及新辅助化疗放射治疗 (NCRT) 或辅助化疗放射治疗 (ACRT) 以及手术.
- 了解NCRT与ACRT在复发模式和存活率方面的比较疗效对于优化患者管理至关重要.
研究的目的:
- 用NCRT和ACRT治疗ESCC患者之间的复发模式和生存结果进行比较.
- 确定影响不同化疗和放射治疗方案的患者生存的预后风险因素.
主要方法:
- 在2018-2020年期间治疗的267名局部晚期ESCC患者的回顾性分析.
- 患者被分为NCRT (n=181) 和ACRT (n=86) 组,其次是倾向性得分匹配,以创建可比较的组 (每组n=74).
- 复发类型,地点,频率,时间,总生存率 (OS),无病生存率 (DFS) 和预后因素的比较.
主要成果:
- 与ACRT组 (33.8%) 相比,NCRT组的复发率明显更高 (59.5%).
- 该ACRT组表现出更好的3年整体生存率 (67.8%) 比NCRT组 (50.6%).
- 在ACRT组中,无病生存期 (DFS) 显著改善 (P<0.001).
结论:
- 在ESCC患者的NCRT和ACRT之间观察到OS和DFS的显著差异.
- 与NCRT相比,ACRT与更低的复发率和更好的生存结果有关.
- 病理N阶段,边缘状态,T阶段,性别和治疗方案被确定为独立的预后因素.
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