一个随机的双盲,安慰剂控制的试验,在克罗恩氏病患者的阿特苏纳酸和黄素:一个试点研究
Devinder Kumar1,2,3, Uday C Ghoshal4, Vamika Mansi Saigal4
1St George's University of London London UK.
概括
阿特苏纳酸和黄素在维持克罗恩氏病患者的缓解方面显示出有前途,尽管阿扎西奥普林治疗,但患有活跃炎症. 组合疗法在六个月的时间里显示出疾病活性得分的显著改善.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
背景情况:
- 克罗恩氏病 (CD) 的长期缓解具有挑战性,只有不到一半的患者在阿扎西奥普林治疗中保持缓解.
- 尽管有阿扎西奥普林,但持续的疾病活动需要探索替代或辅助疗法.
研究的目的:
- 为了评估阿尔特苏纳酸和黄素在维持CD患者的缓解疗法的有效性,CD患者尽管接受了阿扎西奥普林治疗,但仍患有活跃疾病.
主要方法:
- 一个2x2因子设计随机选择了40名轻度至中度CD患者 (CDAI 150-450) 接受2周至3个月的artsunate,curcumin,两者或安慰剂.
- 用哈维-布拉德肖指数 (HBI),克罗恩病活动指数 (CDAI) 和便calprotectin在多个时间点评估疾病活动,长达6个月.
主要成果:
- 阿特苏纳酸和黄素被很好地容忍,没有报告的不良反应.
- 在6个月后,在治疗组中观察到HBI的显著差异 (p=0.047).
- 从基线到6个月的时间,CDAI和HBI在阿特苏纳酸+黄素组 (分别为p=0.0098和p=0.0070) 和黄素+安慰剂组 (分别为p=0.0431和p=0.0138) 显示了统计学上显著的改善.
结论:
- 与阿尔特苏纳酸和黄素的联合治疗在克罗恩病患者的持续炎症活动的管理中似乎有效.
- 这些发现表明,在特定的CD患者群体中,阿尔特苏纳酸和黄素作为辅助治疗来维持缓解的潜在益处.
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