产前阿片类药物暴露和生命早期的表观基因组:ECHO的结果
Rose Schrott1,2, Henri Garrison-Desany3, Lyndsay Avalos4
1Wendy Klag Center for Autism and Developmental Disabilities, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Journal of substance use
|July 1, 2025
概括
产前阿片类药物暴露可能会改变新生儿的DNA甲基化,特别是在一个CpG部位. 这项研究表明,潜在的表观遗传机制将产前阿片类药物暴露与儿童健康结果联系起来.
科学领域:
- 环境表观遗传学环境表观遗传学
- 发展性毒理学 发展性毒理学
- 围产期健康 围产期健康
背景情况:
- 产前阿片类药物暴露与不利的儿童健康结果有关.
- 表观遗传修饰,如DNA甲基化,是这些效应的潜在机制.
- 调查与产前阿片类药物暴露有关的局部特异性DNA甲基化和表观遗传年龄至关重要.
研究的目的:
- 检查产前阿片类药物暴露与带血中特定CpG部位的DNA甲基化 (DNAm) 之间的关联.
- 评估产前阿片类药物暴露与妊娠表观遗传年龄之间的关系.
- 探索产前阿片类药物暴露导致儿童健康不良结果的潜在表观遗传机制.
主要方法:
- 利用了来自环境影响儿童健康结果 (ECHO) 队列的数据.
- 从母亲的自我报告和/或医疗记录中获得的产前阿片类药物暴露数据.
- 分析了带血中的DNA甲基化,使用线性回归模型,对共变量进行调整.
主要成果:
- 在385个人中,在一个CpG位点 (cg14303187) 的产前阿片类药物暴露和DNA甲基化之间发现了名义上显著的关联.
- 在716名个体中,在产前阿片类药物暴露和妊娠表观遗传年龄之间没有观察到显著的关联.
- 鉴定到的CpG部位 (cg14303187) 显示出与产前阿片类药物暴露的负相关性 (β = -0.012,p = 0.02).
结论:
- 产前阿片类药物暴露名义上与带血中特定的CpG部位的DNA甲基化变化有关.
- 在这项研究中,妊娠表观遗传年龄与产前阿片类药物暴露没有显著的关联.
- 需要进一步的研究来阐明产前阿片类药物暴露对胎儿表观基因组的影响.
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