在COVID-19后恢复支气管切除症患者中,恶化和死亡风险增加
Sang Hyuk Kim1,2,3,4, Jong Seung Kim5,6,7,3,4, Min Ji Kim5,6,8,4
1Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Dongguk University Gyeongju Hospital, Dongguk University College of Medicine, Gyeongju, Republic of Korea.
ERJ open research
|July 1, 2025
概括
患有支气管切除症的人在2019年新冠肺炎 (COVID-19) 恢复后面临更高的死亡风险. 严重的COVID-19在这个人群中显著增加了恶化和死亡风险.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 支气管切除症患者的冠状病毒2019 (COVID-19) 恶化风险增加.
- 在COVID-19后恢复,COVID-19严重程度对支气管切除症严重恶化和死亡率的影响尚不清楚.
研究的目的:
- 为了调查COVID-19严重程度和支气管支气管病患者的结果之间的关联.
- 在这个患者群体中评估COVID-19康复后严重恶化和死亡的风险.
主要方法:
- 从韩国国家医疗保险服务 (2015-2020年) 确定了48342名支气管切除症患者的队列.
- 一项匹配的队列研究比较了2,711名COVID-19幸存者的支气管切除与2,711名倾向匹配的对照.
- 结局包括严重的支气管切除症恶化和死亡率,根据COVID-19的严重程度进行分析 (非严重与严重).
主要成果:
- 与匹配的队列相比,COVID-19队列显示出明显更高的死亡风险 (aHR1.46).
- 患有支气管切除症的严重COVID-19幸存者面临严重恶化 (aHR 2.38) 和死亡率 (aHR 2.99) 的风险增加.
- 在整体COVID-19队列中没有观察到严重恶化风险的显著增加.
结论:
- 在患有支气管切除症的个体中,COVID-19的恢复增加了死亡风险.
- 严重的COVID-19加剧了这种风险,导致严重恶化和死亡率更高.
- 支气管切除症患者需要在COVID-19后进行仔细监测,特别是在严重感染后.
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