结核相关慢性阻塞性肺病的发生率和危险因素
Dong-Hyun Joo1, Min Chul Kim1, Sooim Sin2
1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
概括
这项研究发现,结核病诊断时的年龄较大,吸烟和下肺功能增加了患结核病相关慢性肺炎的风险. 这种情况的发生率在11年的随访期间下降.
科学领域:
- 肺部医学 肺部医学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 慢性阻塞性肺病 (COPD) 是一个重要的全球健康问题.
- 结核病 (TB) 和COPD之间的联系是公认的,但其发病率和风险因素需要进一步调查.
- 了解结核病相关的COPD对于有效的疾病管理至关重要.
研究的目的:
- 为了评估结核病相关的COPD的发病率.
- 识别与其发展相关的风险因素.
- 为了比较COPD患者和没有COPD患者结核病后治疗的特征.
主要方法:
- 一个多中心的,回顾性队列研究,涉及351名患者在韩国治疗结核病.
- 随访时间为11年 (132个月),数据以四分位数进行分析.
- 使用波桑回归比较的发病率;通过多变量逻辑回归确定的风险因素.
主要成果:
- 结核病相关的COPD的总体原始发病率为20.56/1000人/年.
- 确定的风险因素包括结核病诊断时的年龄,较低的基线FEV1 (<80%),吸烟和多层结核病的参与.
- 在11年的随访期间,发病率显著下降 (IRR 0.49,p=0.027).
结论:
- 在结核病诊断时的年龄较大,吸烟,较低的基线FEV1和广泛的结核病参与是发展COPD的重要风险因素.
- 结核病相关的COPD的发病率在结核病治疗完成11年后呈现下降趋势.
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