慢性压力的细胞衍生的表观遗传学标记区分乳腺癌表现型
Amrita Acharya1, Anthony S Zannas1,2,3
1Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
The Yale journal of biology and medicine
|July 1, 2025
概括
慢性压力会影响乳腺癌 (BC) 的表观遗传学. 压力的DNA甲基化 (DNAm) 标记在BC瘤中较高,与高级阶段和等级相关,这表明压力和BC进展之间存在联系.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 癌症生物学 癌症生物学
- 环境健康 环境健康
背景情况:
- 乳腺癌 (BC) 是女性癌症的主要原因,经常表现出对治疗的耐药性.
- 慢性压力与不良癌症结果有关,并且可以改变表观基因组.
- 由于它们的复杂和异质性质,了解压力和BC之间的分子联系至关重要.
研究的目的:
- 调查慢性压力细胞DNA甲基化 (DNAm) 标志物是否可以区分BC表型.
- 探索皮质醇的表观遗传影响,皮质醇是压力反应中的关键激素,在BC.
主要方法:
- 利用暴露于生理皮质醇水平的人类纤维细胞来模拟压力影响.
- 分析了来自两个独立的人类BC队伍的瘤和正常样本中的DNA甲基化模式.
- 确定了与压力标志物相关的特定DNAm位点及其在相关途径中的丰富.
主要成果:
- 与正常组织相比,在BC瘤样本中,压力的甲基组特征显著升高.
- 与压力相关的DNAm标记与更先进的瘤阶段和等级相关.
- 与压力相关的特定DNAm位点在两个队列中的细胞粘附通路中都得到了丰富.
结论:
- 慢性压力的细胞DNA甲基化特征与乳腺癌的进展有关.
- 这些发现为连接压力和BC的分子机制提供了洞察力.
- 证明了使用细胞模型衍生生物标志物的潜力,用于癌症环境表观遗传学研究.
相关概念视频
01:37Epigenetic Regulation
3.1K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.1K
01:19Psychoneuroimmunology: Diabetes and Cancer
67
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
67