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儿童的MASLD:将流行病学趋势与机械和转化方面的进展相结合
Jeffrey B Schwimmer1,2, Sudha B Biddinger3,4, Samar H Ibrahim5
1Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego, School of Medicine, La Jolla, California, USA.
The Journal of clinical investigation
|July 1, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 是儿童日益关注的问题,由早期生活因素和遗传倾向驱动. 儿科MASLD需要量身定制的诊断和干预方法来改善长期结果.
科学领域:
- 儿科肝病学 儿科肝病学
- 代谢障碍 代谢障碍 代谢障碍
- 发展生物学 发展生物学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是儿童中最常见的肝病,发病率越来越高.
- 儿童早期发病的MASLD与发育脆弱性和独特的机制驱动因素有关,与成人呈现不同.
研究的目的:
- 审查儿科MASLD的流行病学,病理生理学和独特特征.
- 突出了对儿科专用诊断和治疗策略的需要.
- 确定针对性治疗和预防的机会.
主要方法:
- 对儿科MASLD的流行病学趋势的审查.
- 分析机械驱动因素,包括围产期影响和遗传因素.
- 检查儿科MASLD中明显的组织学特征.
主要成果:
- 儿科MASLD受围产因素 (母亲肥胖,妊娠期糖尿病) 和遗传变异 (PNPLA3,TM6SF2) 的影响.
- 在儿童中观察到明显的组织学模式,包括周门肥胖症,炎症和纤维化.
- 生命早期的压力因素有助于代谢编程,线粒体功能障碍和表观遗传变化.
结论:
- 儿科MASLD具有独特的病理生理路径和疾病进展.
- 量身定制的诊断和风险分层方法对儿童至关重要.
- 针对早期生命驱动者的干预措施对于减轻疾病负担和改善结果至关重要.
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