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乳头甲状腺癌治疗后第二次原发性恶性病的发生率和风险:单一机构研究研究

Katelyn R Ward¹, Heba Elassar², Jacquelyn Pastewski¹

¹Department of Surgery, Corewell Health William Beaumont University Hospital, Royal Oak.

American journal of clinical oncology

|July 1, 2025

概括

乳头甲状腺癌患者患第二次原发性恶性瘤的风险更高. 放射性治疗 (RAIT) 与这种风险增加无关,但年龄和个人/家庭癌症史是因素.

科学领域:

在瘤学瘤学.
内分泌学在内分泌学.
癌症流行病学癌症流行病学

背景情况:

与一般人群相比,乳头甲状腺癌 (PTC) 患者的非甲状腺第二原发性恶性瘤 (SPM) 发病率更高.
了解PTC患者中SPM的风险因素对于患者的管理和监测至关重要.

研究的目的:

调查PTC患者中SPM的发生率.
确定与SPM发展相关的人口风险因素.
为了检查放射性治疗 (RAIT) 和PTC患者的SPM风险之间的关系.

主要方法:

在2007年1月至2011年1月期间接受治疗的528名PTC患者的回顾性审查.
对人口统计数据,个人和家庭癌症病史以及RAIT使用情况的分析.
使用SEER数据进行比较的标准化发病率计算.

主要成果:

总共有7.6%的PTC患者在9.3年的中位数随访期间发展出SPM,标准化发病率为1.3.
乳腺癌是最常见的SPM (30%).
在RAIT使用/剂量和SPM发展之间没有发现显著的关联. 高龄,个人癌症史和家族癌症史与SPM有关,但不是独立的风险因素.

结论:

放射性治疗 (RAIT) 与乳头甲状腺癌患者的第二次原发性恶性瘤风险增加无关.
年龄和个人或家族癌症史与PTC患者的SPM风险有关,需要进一步调查它们的独立作用.

关键词:

皮囊性甲状腺癌是什么?放射性治疗是一种放射性治疗.第二种原发性癌症是第二种癌症.第二个初级恶性瘤.

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