冷解胚胎的妊娠结果与来自冷解胚胎的胚胎:一项回顾性研究
Huy Phuong Tran1,2,3,4, Tuyet Thi-Diem Hoang4, Ha Le-Bao Tran1,2,3
1Faculty of Biology and Biotechnology, University of Science, Ho Chi Minh City, Vietnam.
International journal of fertility & sterility
|July 1, 2025
概括
将冷解的裂胚胎培养到胚胎囊阶段,显示出与转移冷解的胚胎囊类似的妊娠结果. 然而,这种扩展培养方法增加了胚胎学家的工作量和取消风险,这表明冷解芽细胞移植更有效.
科学领域:
- 生殖医学和胚胎学
- 辅助生殖技术 (ART) 是一种辅助生殖技术.
- 在体外受精 (IVF) 的结果
背景情况:
- 有限的数据存在于冷解裂期胚胎的结局,这些胚胎被培养到囊胚阶段.
- 需要比较从延长裂变阶段胚胎培养转移的芽细胞与直接冷解芽细胞转移之间的情况.
研究的目的:
- 为了比较两个胚胎移植策略之间的怀孕结果.
- 策略1:转移来自冷解的分离胚胎的胚胎胚胎,培养了额外的两天 (D3-5组).
- 策略2:转移先前冷解的胚胎囊 (D5组).
主要方法:
- 从2022年1月到2023年12月对167名患者 (D3-5组) 和342名患者 (D5组) 的回顾性观察队列分析.
- 收集了关于阳性人类胆性腺激素 (hCG) 率,临床怀孕率,正在进行的怀孕率,活产率,怀孕失败率和周期取消率的数据.
- 两组之间怀孕结果的统计比较.
主要成果:
- D3-5群体的取消率很高 (65.3%),主要是由于缺少胚胎细胞发育 (85.3%).
- 在D3-5和D5组之间,怀孕结果是可比的:阳性hCG (52%对53%),临床怀孕 (45%对48%),正在进行的怀孕 (34%对33%),活产 (31%对29%),怀孕失败 (21%对24%).
- 在任何评估的怀孕参数中都没有观察到统计学上显著的差异 (P > 0.05).
结论:
- 培养冷解的裂变阶段胚胎,再添加两天到囊胚阶段,对于怀孕结果来说,与冷解的囊胚转移并没有劣势.
- 这种扩展培养方法显著增加了胚胎学家的工作量和周期取消的风险.
- 在辅助生殖技术中,转移冷解的胚胎囊似乎是一个更有效和更为友好的选择.
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