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Updated: Sep 17, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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四面体脱氧核糖核酸工程多价值的溶酶体准金氏体,用于增强和双膜蛋白质降解

Haoran Zhu1, Guihua Zhang1, Yuhua Ning1

  • 1The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, the Key Laboratory of Chemical Biology of Fujian Province, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.

ACS nano
|July 1, 2025
PubMed
概括

四面体DNA和基于aptamer的多价值溶酶体向仿真体 (TDA-MLYTAC) 提高了蛋白质降解的效率. 这种新的方法改善了细胞吸收和稳定性,通过溶酶体路径进行向蛋白质去除.

关键词:
在LYTAC中,我们可以使用LYTAC一个aptamer的应用程序.这是一个多价值的多元化.有针对性的蛋白质降解降解.四面体DNA是四面体的DNA.

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