癌细胞和癌症相关纤维细胞之间的密切空间相互作用抑制抗瘤免疫力
Yuto Naoi1,2, Yumi Inukai1,3, Tomoka Izumikawa1
1Department of Tumor Microenvironment, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Cancer immunology research
|July 1, 2025
概括
与癌细胞密切相互作用的癌症相关纤维细胞 (CAFs) 抑制抗瘤免疫力比物理障碍更强. 针对这些相互作用和皮奥斯可以提高癌症免疫疗法的疗效.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物技术是生物技术.
背景情况:
- 已知与癌症相关的纤维细胞 (CAF) 在瘤微环境中抑制抗瘤免疫力.
- 它们作为免疫细胞透的物理障碍物的作用已经确立,但它们与癌细胞的确切空间关系及其对免疫力的影响尚不清楚.
研究的目的:
- 研究CAF和癌细胞之间的空间关系对抗瘤免疫力的影响.
- 探索向CAF与癌细胞相互作用的潜在分子机制和治疗潜力.
主要方法:
- 利用3D生物打印来创建纤维细胞 (FB) 和癌细胞的受控空间结构.
- 分析了混合与周围FB分布对体外和体内瘤免疫力的影响.
- 研究了TGFβ和环素 (Postn) 交叉交谈以及Postn敲击的影响.
- 与患者预后和头和肺癌中的免疫细胞透相关的CAF分布模式.
主要成果:
- 混合分布的CAF和癌细胞比周围的FB屏障更有效地抑制了抗瘤免疫力.
- 这种混合分布通过TGFβ和环素交叉交谈促进了免疫抑制.
- 在CAFs下降后降低了TGFβ,增强了体外和体内瘤免疫力.
- 从临床角度来看,混合的CAF-癌细胞分布与更糟糕的预后和更低的CD8+T细胞透率相关,这些患者接受PD-1阻断疗法.
结论:
- CAF与癌细胞之间的密切空间相互作用,而不仅仅是物理障碍,是免疫抑制的关键驱动因素.
- 向CAF-癌细胞相互作用和环素是增强癌症免疫疗法的有希望的策略.
- 3D生物打印为研究瘤微环境动态和空间关系提供了一个有价值的平台.
更多相关视频
08:02Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles
Published on: May 14, 2021
5.8K
07:44Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
Published on: November 28, 2019
7.6K
相关概念视频
The Tumor Microenvironment
6.8K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.8K
Tumor Immunotherapy
667
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
667
Cancer Stem Cells and Tumor Maintenance
5.0K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
5.0K
Adaptive Mechanisms in Cancer Cells
5.9K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.9K
Metastasis
5.7K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.7K
