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Kia Lærke Madsen1,2, Mette Tranberg3,4,5, Pia Nørgaard4
1Bandim Health Project, INDEPTH Network, Bissau, Guinea-Bissau.
Journal of medical virology
|July 1, 2025
概括
在几内亚比绍,需要进行宫癌查. 这项研究发现,艾滋病毒感染妇女中存在高高风险的人类乳头瘤病毒 (hr-HPV) 患病率,支持尿液自取样本用于HPV检测,并将其纳入艾滋病毒护理.
科学领域:
- 全球健康 全球健康
- 在瘤学瘤学.
- 病毒学 病毒学
背景情况:
- 在几内亚比绍,子宫癌 (CC) 查在很大程度上不存在.
- 有限的数据存在高风险人类乳头瘤病毒 (hr-HPV) 在艾滋病毒感染者 (WLWH) 妇女的流行.
研究的目的:
- 评估第一空尿 (FVU) 和阴道自取样本对HPV检测的可接受性.
- 为了确定在几内亚比绍的WLWH中h-HPV的流行率.
- 评估FVU和阴道样本之间的hr-HPV基因型一致性.
主要方法:
- 一项涉及498名年龄在18-64岁之间的WLWH的多中心横截面研究.
- 配对的FVU和阴道样本在九个艾滋病毒诊所进行了自我采集.
- 使用Allplex HPV-HR测定进行了HPV DNA测试;通过问卷评估了可接受性.
主要成果:
- 78%的参与者检测出 hr-HPV 的阳性.
- 在样本类型之间观察到良好的hr-HPV基因型一致性 (κ范围为0.64-0.78).
- HPV52和HPV58是最常见的基因型 (每种21%).
- 无论是FVU还是阴道自取样都得到了很好的接受,对FVU有偏好.
结论:
- 在几内亚比绍,基于临床的FVU和阴道自取样是可行的和可接受的WLWH.
- 高水平的HPV流行率凸显了在艾滋病毒护理计划中迫切需要基于HPV的CC查和治疗.
- 在这个人群中,尿液自取样是HPV检测的首选方法.
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