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基因型分析和临床发现与日本米埃县的萨波病毒相关的急性胃肠炎,2010-2022年

Hajime Kusuhara¹, Yen Hai Doan², Akihito Kobayashi^1,3

¹Mie Prefecture Health and Environment Research Institute, Mie, Japan.

Journal of medical virology

|July 1, 2025

概括

萨波病毒 (SaV) 在儿童中引起急性胃肠炎. 这项研究确定了常见的SaV基因型和临床症状,揭示了日本米埃县持续的遗传变化和与年龄有关的趋势.

科学领域:

病毒学病毒学
儿童传染病儿童传染病
公共卫生监督公共卫生监督

背景情况:

萨波病毒 (SaV) 是全球急性胃肠炎的一个重要原因.
了解SAV流行病学和临床表现对于有效的公共卫生干预至关重要.

研究的目的:

调查儿童胃肠炎病例中萨波病毒的流行率和遗传多样性.
分析临床表现,并确定与SAV感染相关的年龄相关趋势.

主要方法:

从儿童患者 (2010-2022) 获得的236个萨波病毒阳性便样本的回顾性分析.
158个SaV菌株的全基因组或几乎全基因组测序.
遗传学分析以确定基因型分布和遗传进化.
对症状和年龄人口统计的临床数据审查.

主要成果:

基因型GI.1是最常见的,其次是GII.3和GII.1在九种检测到的基因型中.
遗传学分析表明,随着时间的推移,在流行的SaV基因型中存在持续的遗传变化.
腹 (68.4%) 和吐 (61.6%) 是主要症状,在3岁以上的儿童中吐增加.
观察到与不同的SaV基因型共感染和再感染.

结论:

这项研究提供了全面的洞察力萨波病毒基因型的流行率和儿科胃肠炎的遗传演变.
临床发现突出了关键症状和特定年龄的趋势,为诊断和管理提供了信息.
持续的监测和遗传监测对于了解和控制萨波病毒疫情至关重要.

关键词:

临床症状临床症状基因分析遗传分析混合感染混合感染.重新感染的情况.这种病毒是sapovirus.

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