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临床诊断的新生儿黄与自闭症之间的关联:瑞典基于登记的队列研究
Aleksandra Kanina1, Zhou Li1, Mina Rosenqvist1
1Department of Medical Epidemiology & Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Acta paediatrica (Oslo, Norway : 1992)
|July 1, 2025
概括
新生儿黄不会增加自闭症的风险. 早期生命黄与自闭症的关联是由早产和低出生体重解释的,而不是直接联系.
科学领域:
- 神经发育障碍 神经发育障碍
- 儿科卫生保健 儿科卫生保健
背景情况:
- 新生儿黄在新生儿中很常见.
- 新生儿黄与包括自闭症在内的神经发育结果之间存在潜在的联系.
- 早期生活中的混因素可能会影响这种关联.
研究的目的:
- 调查新生儿黄与自闭症风险之间的关联.
- 为了确定围产期风险因素是否混新生儿黄和自闭症之间的关系.
主要方法:
- 基于人口的队列研究,对超过160万在瑞典出生的人进行了研究 (1992-2010).
- 利用瑞典的健康登记册,获取有关黄和自闭症诊断的数据.
- 采用考克斯回归分析来估计危险比率,对共变量进行调整.
主要成果:
- 在新生儿黄和自闭症 (HR=1.48) 之间观察到初始关联.
- 经过对妊娠年龄和出生体重进行调整后,这种关联显著减弱.
- 在完全的共同变量调整后,新生儿黄和自闭症之间的关联被取消了 (HR=1.02).
结论:
- 新生儿黄和自闭症之间观察到的关联被围产因素,特别是早产所混.
- 这项研究强调了在研究早期暴露和自闭症的研究中考虑和调整围产期混因素的关键重要性.
- 研究结果表明,新生儿黄和自闭症之间的联系不是直接的,而是受到潜在的围产期疾病的影响.
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