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相关概念视频

Sleep Apnea01:21

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Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Physical assessment of the respiratory tract through inspection is a crucial step in understanding the patient's respiratory health. It provides insights into the functioning of the respiratory system, the musculoskeletal structure, and even the patient's nutritional status. This comprehensive approach involves observing several vital aspects: chest configuration, breathing patterns, respiratory rates, skin color, and use of accessory muscles.
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血清Ang1,Ang1-7和Mas水平作为阻塞性睡眠呼吸暂停综合征的潜在生物标志物.

Gizem Çil1, Ömer Araz2, Buğra Kerget2

  • 1Department of Pulmonary Diseases, Siirt Education and Research Hospital, Siirt, Türkiye.

Biomarkers in medicine
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概括

降低了血管新生素1-7 (Ang1-7) 的水平,血管新生素1 (Ang1) 和Mas受体与阻塞性睡眠呼吸暂停 (OSA) 的严重程度有关. 这些生物标志物在识别中度至重度OSA病例方面表现有前途.

关键词:
英格兰 1-4更多 更多 更多 更多这就是RAAS RAAS.阻塞性睡眠呼吸暂停综合征聚类人体图像 (polysomnography) 是一种多人体图像.

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科学领域:

  • 心血管研究研究心血管研究
  • 睡眠医学 睡眠医学
  • 生物标志物发现发现

背景情况:

  • 阻塞性睡眠呼吸暂停 (OSA) 破坏了炎症和抗炎症的平衡.
  • 氨酸- ангиотензин系统在与OSA相关的炎症过程中发挥作用.

研究的目的:

  • 为了研究血清中血管新素1 (Ang 1),血管新素1-7 (Ang 1-7) 和Mas受体水平之间的关联以及OSA的严重程度.
  • 评估这些生物标志物的诊断潜力在分层的OSA患者中.

主要方法:

  • 190名受试者接受了多睡眠检查,以评估OSA的严重程度 (呼吸暂停-呼吸暂停指数,AHI).
  • 使用ELISA量化Ang1,Ang1-7和Mas受体的血清度.
  • 患者被分为控制,轻度,中度和重度OSA组.

主要成果:

  • 与轻度OSA和对照组相比,中度和重度OSA组的Ang 1-7,Ang 1和Mas的血清水平明显较低 (p < 0.001).
  • 在这些生物标志物和AHI之间观察到显著的负相关性 (例如,Ang 1-7:R = -0.597,p < 0.001).
  • 接收器操作特征 (ROC) 分析表明强大的诊断性能,曲线下面面积 (AUC) 值为Ang1-7的0.864,Ang1的0.873和Ang1的0.837,Mas的0.837,以及高灵敏度 (97-98%).

结论:

  • 降低Ang1-7,Ang1和Mas的血清水平与OSA严重程度的增加有关.
  • 这些生物标志物具有显著的诊断价值,并可能有助于中度至重度OSA患者的临床分层.