未来的队列研究 eDiary急性疼痛评估在状细胞疾病在第三个三个月和产后
Eugenia Vicky Asare1, William Kwesi Ghunney1, John Benaiah Ayete-Nyampong2
1Ghana Institute of Clinical Genetics/ Korle-Bu Teaching Hospital, Ghana.
Blood advances
|July 1, 2025
概括
患有状细胞疾病 (SCD) 的孕妇在怀孕期间比分娩后经历的急性疼痛事件要多得多. 每日eDiary数据显示,怀孕期间SCD疼痛的发病率高出1.85倍.
科学领域:
- 产科和妇科 产科和妇科
- 血液学 血液学 血液学
- 公共卫生 公共卫生
背景情况:
- 患有状细胞疾病 (SCD) 的孕妇面临患病和死亡的风险增加.
- 众所周知,SCD中急性血管闭塞性疼痛事件在怀孕期间增加,特别是在第三个三个月和产后期.
- 家庭管理的疼痛事件往往被低估,需要对日常自我报告的疼痛进行研究.
研究的目的:
- 为了比较怀孕期间与产后期间患有SCD的孕妇自我报告的急性血管闭合性疼痛事件的发生率.
- 为了测试一种假设,即急性SCD疼痛在怀孕期间 (第三季度到产后) 比分娩后更频繁.
主要方法:
- 展望研究涉及加纳33名患有SCD的孕妇使用eDiary移动应用程序进行日常自我报告.
- 收集了从怀孕第三个月到产后九个月的急性SCD疼痛事件的数据.
- 分析怀孕和产后期间自我报告的疼痛发病率.
主要成果:
- 与产后期相比,怀孕期间观察到自我报告的急性SCD疼痛事件的发生率高出1.85倍 (0.74对0.40事件/人/月).
- 怀孕和产后疼痛发病率的差异在统计学上是显著的 (p<0.001).
- 33名参与者完成了71.5%的预期电子日记条目.
结论:
- 怀孕中患有SCD的孕妇在怀孕期间经历的急性疼痛事件的频率要高得多,特别是在妊娠的第三季度和产后期.
- 通过电子日记每日自我报告捕捉了家庭管理疼痛的关键数据,突出了怀孕期间增加的发病率.
- 研究结果强调,需要加强在怀孕期间SCD疼痛的管理策略.
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