移动瘤的外围Foxp3高调节性T细胞导致肝细胞癌的预后不佳
Chien-Hao Huang1,2, Wei-Ting Ku1,3, Jayashri Mahalingam1,4
1Division of Hepatology, Department of Gastroenterology-Hepatology Linkou Medical Center, Chang Gung Memorial Hospital, Kweishan, Taoyuan, Taiwan.
Hepatology (Baltimore, Md.)
|July 1, 2025
概括
调节性T细胞 (Tregs) 的一个特定子集,称为外围Foxp3高Tregs,迁移到肝细胞癌 (HCC) 瘤中. 它们在血液中的比例预测了患者的生存率和复发风险.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 单细胞基因组学 单细胞基因组学
背景情况:
- 调节性T细胞 (Tregs) 在肝细胞癌 (HCC) 进展中起着关键作用.
- 系统性Treg耗尽可能导致自身免疫,需要有针对性的方法.
- 现有的Treg分类缺乏共识,突出显示异质性.
研究的目的:
- 使用单细胞CITE-seq.q.将Treg亚型分类为HCC.
- 整合来自瘤,非瘤和血液样本的数据.
- 验证Treg分类的临床相关性和预后价值.
主要方法:
- 在8名HCK患者的51,067个CD4+T细胞上进行了CITE-seq.
- 在96名HCC患者和53名健康捐赠者的验证结果使用流细胞计和功能测定.
- 分析了临床数据的预后价值.
主要成果:
- 确定了一个外围的Foxp3高Treg子集,通过激活的表型迁移到瘤部位.
- 发现CCL5/CCR5轴对Treg招聘至关重要.
- 证明的外围Foxp3高Treg百分比预测HCC的整体存活率和早期复发.
结论:
- 外围Foxp3高Tregs通过CCR5-CCL5轴迁移到HCC瘤中,并在对细胞因子的反应中成熟.
- 周围Foxp3高Treg比例与瘤存在相关,作为潜在的HCC生物标志物.
- 这个Treg子集为HCC结果预测提供了一个有希望的目标.
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