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农药对食虫蝙蝠的系统性影响:一种蛋白质组学方法

Natalia Sandoval-Herrera^1,2,3, Linda Lara-Jacobo⁴, Paul A Faure⁵

¹Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada.

Integrative and comparative biology

|July 1, 2025

概括

农药暴露会伤害蝙蝠,影响它们的免疫和认知功能. 蛋白质学揭示了Chlorpyrifos改变了对免疫反应至关重要的蛋白质,可能增加疾病传播风险.

科学领域:

生态毒理学生态毒理学
蛋白质组学是指蛋白质组学.
哺乳动物生物学哺乳动物生物学

背景情况:

蝙蝠对害虫控制至关重要,但在农业地区面临农药风险.
杀虫剂可以损害蝙蝠的免疫功能,认知和运动能力,威胁到它们的生存.

研究的目的:

使用蛋白质学研究pyrifos (CPF) 对大棕色蝙蝠 (Eptesicus fuscus) 的系统性影响.
了解环境相关的CPF度如何影响蝙蝠健康和生态作用.

主要方法:

在暴露于CPF的蝙蝠的血样本上使用非向蛋白质组.
蝙蝠被用环境相关度的CPF养了3天或7天.
蛋白质组分析确定了100多种蛋白质,暴露后丰度发生了变化.

主要成果:

暴露于CPF显著改变了参与细胞通信,新陈代谢和DNA维护的蛋白质.
调节免疫反应,T细胞激活和炎症的关键蛋白质显示出显著的变化.
这些变化表明蝙蝠的免疫功能下降和对感染的易感性增加.

结论:

蛋白质组学是评估蝙蝠和其他易受伤害的物种中农药毒性的宝贵工具.
暴露于CPF可能会损害蝙蝠的免疫力,可能增加病原体脱落和传播的风险.
这些发现对One Health有意义,考虑到蝙蝠在动物传染病库中的作用.

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