在肌肉侵入性膀癌中,新辅助治疗模式和生物标志物选择
Wei He1, Jiaxin Xie1, Ziwei Wang1
1Department of Urology, The First Affiliated Hospital, Naval Medical University, Shanghai, 200433, China.
Discover oncology
|July 1, 2025
概括
针对肌肉侵入性膀癌 (MIBC) 的新辅助疗法正在发展,包括免疫检查点抑制剂和抗体-药物联合体等新疗法. 生物标志物研究对于为膀癌患者选择最佳的新辅助疗法至关重要.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 翻译研究是翻译研究.
背景情况:
- 针对肌肉侵入性膀癌 (MIBC) 的新辅助疗法正在推进风险适应性策略.
- 基于的化疗,特别是剂量密集的MVAC (ddMVAC),是当前的标准.
- 新型药物如免疫检查点抑制剂 (ICI),FGFR抑制剂和抗体-药物结合剂 (ADC) 正在出现.
研究的目的:
- 审查MIBC中新辅助治疗模式的演变.
- 突出基于证据的医学和翻译性研究成果.
- 为MIBC新辅助疗法提供对未来实践和研究方向的见解.
主要方法:
- 对MIBC的新辅助治疗现有文献的全面审查.
- 专注于从临床试验和翻译研究中获得的高质量的证据.
- 检查预测模型和新兴生物标志物的研究.
主要成果:
- 目前正在进行的试验 (KEYNOTE-B15,RC48-C017,NIAGARA) 正在评估新辅助疗法的新组合.
- 使用组织学,遗传学和有机体的预测模型显示出希望,但面临缓慢的临床转化.
- 需要探索MIBC的遗传异质性,并验证患者选择的生物标志物.
结论:
- 对MIBC的新辅助治疗正在迅速发展,超越了传统化疗.
- 新型药物和组合疗法为患者提供了新的希望,特别是对于不适合使用西斯的患者.
- 加快生物标志物验证对于优化MIBC中新辅助疗法选择至关重要.
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