心脏代谢障碍影响心肌[18F]氧葡萄糖吸收 - - 对诊断PET/CT成像的影响
Suvi Hartikainen1,2, Ville Vepsäläinen3, Tuomo Tompuri4
1Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland. suvi.hartikainen@pshyvinvointialue.fi.
心脏代谢障碍,包括胰岛素抵抗,与心脏葡萄糖代谢减少有关. 这项研究发现,这些条件预测了基因饮食和禁食后心肌[18F]FDG吸收的降低.
科学领域:
- 心脏病学 心脏病学
- 核医学就是核医学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 骨肌中的胰岛素抵抗可能延伸到心肌,将心脏代谢障碍与心脏葡萄糖代谢联系起来.
- 研究心脏代谢障碍与心肌糖吸收之间的关系对于了解心脏健康至关重要.
研究的目的:
- 为了确定心脏代谢障碍是否预测心肌中压抑的[18F]氧糖 ([18F]FDG) 摄取.
- 使用正子发射断层扫描/计算机断层扫描 (PET/CT) 分析基因素饮食和禁食患者的心脏代谢.
主要方法:
- 100名患者接受了FDG-PET/CT,在服用了1-2天的饮食和12小时的禁食后.
- 测量血液参数 (葡萄糖,胰岛素,BHB,脂质,FFA),计算HOMA-IR,并通过CT评估内脏/皮下脂肪和脂肪肝.
- 定义足够的心肌[18F]FDG吸收抑制作为吸收等于或低于血池背景.
主要成果:
- 充分的心肌[18F]FDG吸收抑制与更高的BHB,FFA和甘油三水平以及更低的肝衰减比率有关.
- 在男性中,较低的HDL胆固醇,高的甘油三,高的HOMA-IR,内脏脂肪,脂肪肝和高血压预测了足够的抑制.
- 在女性中,BHB和FFA的升高是足够抑制的显著预测因素.
结论:
- 心脏代谢障碍与心肌[18F]FDG吸收减少有关.
- 胰岛素耐药性和其他心脏代谢风险因素预测吸收减弱,特别是在男性中.
- 对性饮食和禁食的代谢反应显著影响女性心肌[18F]FDG吸收.
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