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孕产妇的肥胖会通过减弱胎儿的FGF21信号来损害胎儿的棕色脂肪生成

Lun Hua¹, Wenxue Shen¹, Dengfeng Gao²

¹Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, Sichuan 611130, China; Key Laboratory for Animal Disease-Resistant Nutrition of the Ministry of Education of China, Sichuan Agricultural University, Chengdu, Sichuan 611130, China; Key Laboratory of Animal Disease-Resistant Nutrition of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.

|July 1, 2025

概括

孕产妇的肥胖会损害胎儿棕色脂肪组织 (BAT) 的发育. FGF21信号是胎儿BAT形成和预防后代代谢问题的关键,提供了潜在的治疗点.

科学领域:

代谢研究研究代谢研究
发展生物学发展生物学
内分泌学在内分泌学.

背景情况:

孕产妇的肥胖会对胎儿棕色脂肪组织 (BAT) 的发育产生负面影响,增加后代代谢障碍的风险.
关联孕产妇肥胖与胎儿BAT形成受损的潜在机制仍然不太清楚.

研究的目的:

调查纤维细胞生长因子21 (FGF21) 在孕产妇肥胖的情况下胎儿BAT发育中的作用.
确定潜在的治疗策略,以抵消孕产妇肥胖对胎儿的不良影响.

主要方法:

从肥胖和对照女性的胎儿骨间BAT (iBAT) 的单核转录组分析.
在母体和胎儿循环中测量循环FGF21水平.
评估iBAT发育和后代的发热功能.
评估产后FGF21补充剂的影响.

主要成果:

孕产妇的肥胖改变了胎儿iBAT中的细胞异质性,影响了后代的发热.
肥胖女性的FGF21水平升高,但由于转胎盘转移受损,胎儿的FGF21水平降低.
孕产妇的FGF21对于胎儿的棕色脂肪生成和预防代谢功能障碍至关重要.
产后FGF21补充改善了由母亲肥胖引起的IBAT发育受损.

结论:

FGF21信号传递对于调节胎儿棕色脂肪生成和预防与母亲肥胖相关的代谢并发症至关重要.
针对FGF21信号提供了一个有希望的治疗途径,以减轻母亲肥胖对胎儿发育的有害影响.

关键词:

这是BATBATBAT.CP:新陈代谢过程中的新陈代谢.FGF21FGF21FGF21FGF21FGF21FGF21FGF21FGF21FGF21FGF21F 孕产妇的肥胖症孕产妇的肥胖症热生成是一种热生成.

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