菌株成像对风险分层的作用在Fontan患者中,他们的心室喷射分数正常
Ahmed T Abdelhalim1, Ali Ali1, Sara ElZalabany1
1Department of Cardiovascular Medicine, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA.
European heart journal. Cardiovascular Imaging
|July 1, 2025
概括
系统性心室纵向应变 (Echo_LS) 确定Fontan患者患心脏功能障碍和心血管事件的风险较高,即使射出分数正常. 这种成像技术有助于早期风险分层,以改善患者的治疗结果.
科学领域:
- 心脏病学 心脏病学
- 儿童心脏病学 儿童心脏病学
- 心声回声图 (Echocardiography) 是一种心声回声图.
背景情况:
- 系统性心室 (SV) 应变成像对于检测先天性心脏病中的缩功能障碍至关重要.
- 它在Fontan患者的风险分层中的实用性仍然是研究不足的.
研究的目的:
- 调查是否减少的SV纵向应变 (Echo_LS) 预测了Fontan患者在正常基线SV射出分数 (Echo_EF) 的进展性静脉功能障碍,神经激素激活和心血管事件.
主要方法:
- 成年Fontan患者的正常基线Echo_EF (>50%) 被评估使用Echo_LS的斑点跟踪回声心脏学.
- 患者被分为减少 (≤-18%) 和正常的Echo_LS组.
- 随访心声图和临床事件分析了超过36个月的时间.
主要成果:
- 在272名患者中,98名 (36%) 患有Echo_LS降低.
- 减少的Echo_LS组显示Echo_EF的时间下降明显更严重,新发性SV缩功能障碍的发病率更高,NT-proBNP升高更大.
- 减少的Echo_LS与84%的心血管事件风险增加有关 (调整后危险比1.84,P = 0.009).
结论:
- 声心谱纵向应变 (Echo_LS) 增强了Fontan患者的风险分层,这些患者的喷射分数正常.
- Echo_LS可能使早期干预能够改善这一群体的长期结果.
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