巨细胞反应和记忆的表观遗传和代谢调节
Maria G Daskalaki1,2, Ioanna Lapi2,3, Avery Ellen Hurst1,2
1Laboratory of Clinical Chemistry, School of Medicine, University of Crete, Heraklion, Greece.
Journal of immunology (Baltimore, Md. : 1950)
|July 1, 2025
概括
巨细胞可以通过表观遗传和代谢变化来培养训练有素的免疫力,从而影响先天免疫反应. 这些变化受到激素,代谢障碍的影响,并起源于造血干细胞,提供治疗潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 巨细胞是关键的先天性免疫细胞,可以发展非特异性记忆,称为训练免疫.
- 训练有素的免疫包括表观遗传修饰和代谢重编程,增强巨细胞的反应能力.
- 诸如激素,细胞因子,基因和代谢障碍等因素可以调节巨细胞的反应能力和表观遗传情景.
研究的目的:
- 审查最近关于巨细胞记忆的表观遗传和代谢调节的证据.
- 突出性激素和代谢因素对巨细胞反应能力的影响.
- 探索针对炎症性疾病中的表观遗传调节者的治疗潜力.
主要方法:
- 关于巨细胞记忆,表观遗传调节和代谢影响的最新科学文献的综述.
- 讨论性别差异和慢性代谢障碍的影响.
- 在长期的改变中探索造血干细胞和祖细胞的参与.
主要成果:
- 巨细胞的反应由表观遗传变化和代谢重新连接来调节,有助于训练免疫力.
- 性激素和代谢障碍 (肥胖,2型糖尿病) 显著改变巨细胞的表观遗传格局和功能.
- 长期持续的巨细胞反应变化源于骨髓的造血干细胞和原始细胞,由于表观遗传变化.
结论:
- 表观遗传和代谢重编程是培养巨细胞免疫力的核心.
- 性激素和代谢失调对巨细胞功能和免疫记忆有深远的影响.
- 向表观遗传调节器是对炎症性疾病的有希望的治疗策略.
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