患有唐氏综合征的个体拥有较低的握力,尾肌肉质量和肌肉质量,与体重相匹配的成年人相比
Ayush Mehra1, Ronald L Snarr2, Angela R Russell3
1School of Health and Rehabilitation Sciences, The Ohio State University, Columbus, Ohio, USA.
Nutrition (Burbank, Los Angeles County, Calif.)
|July 1, 2025
概括
与没有唐氏综合征的同龄人相比,唐氏综合征 (DS) 患者的肌肉质量指数 (MQI) 和手握强度 (HGS) 较低. 这凸显了针对性干预措施的必要性,以提高DS患者的肌肉健康.
科学领域:
- 肌肉骨健康 肌肉骨健康
- 人类生理学 人类生理学
- 遗传学和疾病
背景情况:
- 患有唐氏综合征 (DS) 的个人经历了加速的肌肉骨衰老和肉症,导致功能障碍.
- 有限的研究存在于肌肉质量指数 (MQI) 在成年人与没有DS (NDS) 相比DS.
研究的目的:
- 为了比较体重匹配的患有唐氏综合征和没有唐氏综合征的成年人之间的肌肉质量指数 (MQI).
- 为了研究这些群体之间的形肌肉质量 (ALM) 和手握强度 (HGS) 的差异.
主要方法:
- 12名DS和12名NDS同龄人的体重匹配比较.
- 尾肌瘦质量 (ALM) 通过双能X射线吸收计测量.
- 使用手持式动力表测量手握强度 (HGS);使用ALM和HGS计算MQI.
主要成果:
- 与NDS同龄人相比,DS组表现出明显较低的肌量,ALM和HGS.
- 肌肉质量指数 (MQIARMS和MQIARMS + LEGS) 在DS患者中明显较低.
- 对于右,左和总和测量,NDS组显示出更高的HGS (P < 0.01).
结论:
- 与没有唐氏综合征的体重匹配个体相比,患有唐氏综合征的成年人表现出肌肉质量,肌肉质量和力量的减少.
- 研究结果强调了针对性干预措施的必要性,以改善DS患者肌肉健康和功能.
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