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Updated: May 3, 2026

Ex Situ Normothermic Machine Perfusion of Donor Livers

Ex Situ Normothermic Machine Perfusion of Donor Livers

Published on: May 26, 2015

现在是时候在儿科肝移植中引入ex-situ常热机器输液了吗?

Anita Niu¹, Ngee-Soon Lau¹, Mark Ly¹

¹Centre for Organ Assessment Repair and Optimisation, Royal Prince Alfred Hospital, Sydney, NSW, 2050, Australia; Australian National Liver Transplant Unit, Royal Prince Alfred Hospital, Sydney, NSW, 2050, Australia; Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, 2050, Australia.

Journal of pediatric surgery

|July 1, 2025

概括

长期正常热机器输液 (LT-NMP) 的儿科肝移植 (LLSG) 显示没有显著的超输液损伤. 这种临床前模型支持儿童肝移植中边缘移植的NMP.

科学领域:

肝病学肝病学是一种肝病学.
移植手术移植手术
机器透技术机器透技术

背景情况:

儿科肝移植面临的挑战是小移植输液和门外超输液损伤.
目前,在儿科接受者中没有使用Normothermic机器输液 (NMP).
这项研究调查了儿童大小的肝移植的NMP.

研究的目的:

在长期常温机器输液 (LT-NMP) 期间,评估左侧段移植 (LLSG) 中的血液动力学条件.
在LT-NMP下评估LLSG中的组织学变化,特别是门外高 perfusion 损伤.
在儿科肝移植中建立NMP的临床前模型.

主要方法:

人类肝脏接受了LT-NMP,并分为LLSG (第2和第3部分) 和右侧扩展移植 (ERG).
测量了血管血液动力学参数,内甲素-1水平和组织病理学.
模拟临床相关的儿科移植的LLSG特征.

主要成果:

分析了10个LLSG,分离后的中位生存时间为5.7天.
在LLSG中,门静脉阻力较高,但重量调整流量与ERG相比较.
随着时间的推移,在LLSGs中没有观察到高 perfusion 损伤的显著组织学迹象,具有较低的内甲蛋白-1水平.

结论:

本研究提出了第一个临床前模型,证明LT-NMP在LLSG的可行性,而不会造成显著的高 perfusion 损伤.
研究结果表明,NMP可以安全地应用于恢复儿科肝移植的边缘移植.
这项研究为在儿科移植环境中扩大NMP应用开辟了道路.

关键词:

在现场使用的常热机器输液器.儿科肝移植手术儿科肝移植手术门外高 perfusion 损伤损伤的损伤.肝脏移植分体移植

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