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在人类尿液中对酸盐火山化加速剂的暴露评估

Lin Gao¹, Yetian Liang¹, Qinle Wang¹

¹Taizhou Central Hospital (Taizhou University Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang 318000, PR China.

Ecotoxicology and environmental safety

|July 1, 2025

概括

人类尿液中存在酸硫化加速剂 (XVA),酸丁和酸氨基含量最高. 这项研究提供了关于人类对这些化合物的暴露的关键数据.

科学领域:

环境化学环境化学
毒理学毒理学毒理学
人类暴露评估评估

背景情况:

酸盐火山化加速器 (XVA) 在尘埃中被广泛检测到,这表明人类潜在的暴露风险.
人体尿液中XVAs的全面研究缺乏,这是暴露的关键生物标志物.

研究的目的:

系统地调查中国泰州市健康成年人尿液中8种XVA同类物质的存在和度.
建立XVA对人类暴露的基本数据,以协助健康风险评估.

主要方法:

在城市泰州市,从218名健康成年人收集了尿液样本.
使用系统检查方法分析了八种XVA同类物质.
确定XVAs的尿度和每日暴露 (DE) 量化.

主要成果:

所有向的XVA化合物都在人体尿样中检测到.
丁酸盐 (KBX) 和胺酸盐 (KAX) 显示出尿液中最高的平均水平.
与女性相比,男性的尿液中KAX,乙烯酸盐 (KPX) 和乙烯酸盐 (KEX) 的平均度较高.
观察到KAX,KBX和KEX的尿度与年龄相关的下降.
最高的平均每日暴露量记录在KBX (906 ng/kg bw/day) 和KAX (718 ng/kg bw/day) 上.

结论:

这项研究提供了人类尿液中XVAs的首次全面分析.
该研究建立了关于人类暴露于XVAs的基本基线数据.
这些发现对于评估XVA暴露对健康的潜在影响至关重要.

关键词:

与年龄相关的差异.与性别有关的差异.人类暴露的人类暴露.尿路生物监测尿路生物监测赞酸盐火山化加速器

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