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Updated: Sep 17, 2025

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通过抑制eIF4E/eIF4G相互作用,发现新型的酸衍生物作为强效的抗癌剂

Binrong Yao1, Chao Zhang1, Ze Ye1

  • 1National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China; State Key Laboratory of National Security Specially Needed Medicines, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China.

European journal of medicinal chemistry
|July 1, 2025
PubMed
概括

一种新型化合物A37通过向真核细胞启动因子4E (eIF4E) 有效地抑制癌细胞生长和瘤发育. 这种有前途的抗癌药物表现出低毒性,表明其临床应用的潜力.

关键词:
这是一种抗癌药物.在HepG2异种移植中,氨酸提亚 (Hydrazinyl thiazole) 是一种一种综合合成 综合合成eIF4E/eIF4G 互动 互动

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