在患有食道癌前细胞变化的患者内镜电穿孔
Laser Arif Bazancir1, Charlotte Egeland2, Rajendra Singh Garbyal3
1Department of Digestive Diseases, Transplantation and General Surgery, Rigshospitalet, University of Copenhagen, Denmark.
概括
电穿孔 (Ca-EP) 是一个安全的新疗法,用于巴雷特食道高度发育不良 (BE HGD). 虽然Ca-EP在一项小型试验中显示出前景,但需要进一步的研究来评估其对食道腺癌的有效性.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 生物医学工程 生物医学工程
背景情况:
- 巴雷特食道高度发育不良 (BE HGD) 携带着进展到食道腺癌 (EAC) 的显著风险.
- 电穿孔 (Ca-EP) 是一种新兴的抗癌方式,利用电脉冲和注射诱导细胞死亡,在癌前条件和正常组织相对保存中已证明有效.
研究的目的:
- 评估在被诊断为巴雷特食道高度形症 (BE HGD) 的患者中电 (Ca-EP) 的安全性和耐受性.
主要方法:
- 六名患有BE HGD的患者在预定的内镜下粘膜剖析 (ESD) 之前六周接受了Ca-EP治疗.
- 在门诊环境下,在全身麻醉下进行治疗.
- 所有不良事件 (AEs) 都被仔细记录下来,患者在治疗后一周内接受了内镜评估.
主要成果:
- 最常见的副作用包括背部疼痛,喉刺激,咳和头痛;没有报告严重的不良事件.
- 在Ca-EP后的过渡性发现包括在一周内高血症 (4名患者),纤维化涂层 (4名患者) 和 (4名患者).
- 虽然五名患者在六周后与状细胞部分重新表皮化,但所有患者都保持了BE HGD诊断.
结论:
- 电穿孔 (Ca-EP) 在BE HGD患者中显示出可接受的安全性.
- 这些发现支持进一步调查Ca-EP在消化不良细胞根除中的有效性及其在治疗食道腺癌中的潜在作用.
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