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Updated: May 10, 2026

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转子体插入导致ctnnb2转录不稳定,导致母体效应斑马鱼 ichabod (ich) 突变

Zsombor Varga1, Ferenc Kagan2, Shingo Maegawa3

  • 1Department of Genetics, ELTE Eötvös Loránd University, Budapest, Hungary.

Biochimica et biophysica acta. Gene regulatory mechanisms
|July 1, 2025
PubMed
概括

斑马鱼中的伊卡博德突变通过破坏Wnt信号,导致腹腔胚胎. 在ctnnb2基因中插入一个转子体会降低其转录稳定性,解释了发育缺陷.

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相关概念视频

Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...