怀孕期间的促炎饮食模式与后代1型糖尿病风险之间的关联:前性队列研究
Rohina Noorzae1,2, Anne Ahrendt Bjerregaard1,3, Thorhallur Ingi Halldorsson1,4
1Department of Epidemiology Research, Statens Serum Institut, Kobenhavn, Denmark.
在怀孕期间,孕妇高含炎症食品的饮食与儿童患1型糖尿病的风险更高有关. 这一发现强调了母亲饮食对早期免疫发育和疾病预防的重要性.
科学领域:
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 导致1型糖尿病的免疫媒介过程可能起源于胎儿发育期间.
- 怀孕期间母亲的饮食是潜在的环境因素,影响后代患1型糖尿病的风险.
研究的目的:
- 调查怀孕期间母亲的炎症饮食与后代患1型糖尿病的风险之间的联系.
主要方法:
- 利用了来自丹麦国家出生队列 (DNBC) 的数据,其中包括67,701对母婴.
- 从食物频率问卷中计算出母体经验性饮食炎症指数 (EDII) 的得分.
- 采用考克斯回归分析来检查母体EDII分数与通过注册表链接获得的儿童1型糖尿病诊断之间的关联.
主要成果:
- 观察到母亲的EDII分数与后代1型糖尿病风险之间存在显著的关联.
- 每增加1个单位的母体EDII得分与16%的1型糖尿病发病率增加有关 (95%CI2%至32%).
- 在对相关共变量进行调整后,这种关联仍然显著.
结论:
- 在怀孕期间以促炎食物为特征的孕产妇饮食与儿童患1型糖尿病的风险增加有关.
- 研究结果表明,母亲的营养在1型糖尿病的发病过程中起着作用.
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