同时出现间歇性肺炎和由梅萨拉诱导的急性肝炎
Daniel Wang1,2, Dolores Vela Serrano3, Lina Camacho-Arteaga4
1Clinical Pharmacology, Hospital Vall d'Hebron, Barcelona, Spain danielwangxie@gmail.com.
BMJ case reports
|July 1, 2025
概括
用于性结肠炎的梅萨拉可以导致肺部和肝脏受损. 这一案例凸显了在患有炎症性肠病和不明原因症状的患者中考虑药物毒性的重要性.
科学领域:
- 胃肠病学 胃肠病学
- 肺部病理学 肺部病理学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 性结肠炎 (UC) 呈现出胃肠道和肠外症状.
- 诊断肠外表现 (EIMs) 是复杂的,通常需要差异诊断与药物诱导的毒性.
- 梅萨拉是一种常见的治疗UC.
研究的目的:
- 报告一个UC患者的病例,该病例患有由梅萨拉引起的肺和肝毒性.
- 对梅萨拉诱导的肺和肝损伤的文献进行审查.
- 强调在与UC相关的EIM中考虑药物毒性的重要性.
主要方法:
- 一个八十多岁的男性患有UC治疗梅萨拉的病例报告.
- 呼吸系统症状和黄的临床表现.
- 诊断评估包括肝脏活检.
- 关于梅萨拉毒性的文献综述.
主要成果:
- 患者患有非特异性间歇性肺炎和肝毒性.
- 梅萨拉被确定为可能的致病因子.
- 梅萨拉戒药和皮质类固醇治疗后症状有所改善.
- 文献表明,梅萨拉诱导的肺和肝毒性可能被低估.
结论:
- 梅萨拉可以引起严重的肺部和肝脏不良反应.
- 在性结肠炎患者的EIM差异诊断中,应考虑药物诱导的毒性.
- 早期识别和撤销违规代理对患者的结果至关重要.
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