血液培养时间到阳性性和Enterococcus faecalis感染性内心炎之间的关系
Christopher Robson1, Hakim Khan2, Ralph K Junckerstorff3
1Monash Infectious Diseases, Monash Health, Melbourne, Vic, Australia; Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Vic, Australia; Australasian Collaboration in Endocarditis, University of Queensland, Herston, Qld, Australia.
Pathology
|July 1, 2025
概括
血液培养中的时间到阳性 (TTP) 在Enterococcus faecalis感染性内心炎 (IE) 和其他来源的E. faecalis bacteremia之间没有显著差异. 需要进一步的研究来澄清TTP.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 由于非特异性症状和当前诊断方法的局限性,感染性内心炎 (IE) 的诊断具有挑战性.
- 反映细菌负载的血液培养的时间对阳性 (TTP) 已显示在区分葡萄球菌IE与其他细菌病的有用性.
- 关于TTP在Enterococcus faecalis IE中的有用性的证据是有限的.
研究的目的:
- 研究血液培养TTP与Enterococcus faecalis IE的诊断之间的关系.
- 评估人口和患者特异性因素对E. faecalis bacteremia中TTP的影响.
- 为了确定TTP是否可以区分E. faecalis IE与其他来源的E. faecalis bacteremia.
主要方法:
- 从2017年至2021年,对患有E. faecalis细菌病的患者进行了回顾性分析.
- 排除多微生物生长,重复发作和血前培养抗生素.
- 确定IE (杜克标准),临床IE,以及其他细菌血源之间的TTP比较.
主要成果:
- 分析了114例E. faecalis细菌病;27例 (24%) 有明显的IE.
- 确定的IE (11.3小时) 和其他来源 (10.6小时) (p=0.07) 之间的TTP中位数没有显著差异.
- 对TTP诊断IE的ROC曲线下的面积为0.62;TTP没有可靠地区分E. faecalis IE.
结论:
- 血液培养物的阳性时间不是Enterococcus faecalis感染性内心炎的显著差异化因素.
- 在E. faecalis IE中TTP的诊断效用需要进一步研究,使用更高质量的证据.
- 人口统计学和患者特异性因素在这个队列中对TTP没有显著影响.
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