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Updated: Sep 17, 2025

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
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Published on: April 21, 2023

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Klf5相邻的超级增强器作为3D基因组结构依赖的转录驱动器,以保护ESC身份

Guangsong Su1,2, Bohan Chen1,2, Yingjie Song2

  • 1Department of Laboratory Medicine and Institute of Precise Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China.

Nature communications
|July 1, 2025
PubMed
概括

超级增强剂 (SE) 和主转录因子 (TF) 调节胚胎干细胞 (ESC) 的身份. 这项研究揭示了一个3D基因组机制,其中SE通过TF相互作用和多基因调节来控制ESC命运.

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