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Updated: Sep 17, 2025

Author Spotlight: Investigating the Motion Dynamics of the Eukaryotic Replisome Components at the Single-Molecule Level
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BAHCC1与H4K20me1结合,以促进MCM复杂载荷和DNA复制

Dongxu Li1,2, Zhi-Min Zhang3,4, Liu Mei1

  • 1Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

Nature communications
|July 1, 2025
PubMed
概括

BAHCC1 串联图多尔域 (TTD) 读取 histone H4K20me1,促进DNA复制原始激活. 这种相互作用招募MCM复合体,对细胞周期进展和DNA修复至关重要.

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