在精神分裂症患者的视觉工作记忆过程中意外地提高了对分心的弹性
Ru-Yuan Zhang1, Yi-Jie Zhao2, Li Zhang3
1Brain Health Institute, National Center for Mental Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine and School of Psychology, Shanghai, China.
Schizophrenia (Heidelberg, Germany)
|July 1, 2025
概括
精神分裂症患者表现出视觉工作记忆 (VWM) 受损,而这种记忆不会因分心而恶化. 与健康的对照组不同,他们的VWM资源分配不受干扰因素的影响,这表明认知灵活性下降.
科学领域:
- 认知神经科学 认知神经科学
- 精神病学是一个精神病学.
背景情况:
- 视觉工作记忆 (VWM) 对认知功能至关重要.
- 精神分裂症 (SZ) 与显著的认知缺陷有关,包括VWM障碍.
- 干扰对SZ中VWM的影响仍然不完全理解.
研究的目的:
- 在分散注意力的精神分裂症中调查VWM缺陷的计算机制.
- 为了比较VWM的表现和SZ患者和健康对照 (HC) 之间的资源分配,不同程度的分心.
- 探索认知控制灵活性在SZ中的VWM性能中的作用.
主要方法:
- 对60名SZ患者和61名HC患者进行了修改后期估计任务.
- 该任务涉及不同尺寸的套件 (1或3件) 和分散注意力的数字 (0或2).
- 使用可变精度模型来分析VWM资源分配的变化.
主要成果:
- 与HC相比,SZ患者的VWM性能普遍受损.
- 分心并没有不成比例地加剧SZ的VWM赤字.
- 干扰因素增加了HC的资源分配变化,但不是SZ,这表明SZ的干扰因素对VWM的干扰较小.
结论:
- SZ患者的VWM过程对外部干扰因素似乎不那么敏感,可能是由于认知控制灵活性降低.
- 这些发现表明精神分裂症认知功能障碍的复杂,非线性相互作用.
- 这项研究为SZ认知缺陷的机制基础提供了新的见解.
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