人类参考图谱知识图的构建,部署和使用.
Andreas Bueckle1, Bruce W Herr2, Josef Hardi3
1Department of Intelligent Systems Engineering, Luddy School of Informatics, Computing, and Engineering, Indiana University, Bloomington, IN, USA. abueckle@iu.edu.
Scientific data
|July 1, 2025
概括
人类参考图谱知识图集了健康成年人体的解剖结构,细胞类型和生物标志物. 这个资源使复杂的生物查询能够跨越多个尺度,推进生物医学研究.
科学领域:
- 生物医学信息学是生物医学信息学.
- 人类解剖学和细胞生物学
- 数据科学是数据科学.
背景情况:
- 人类参考图谱 (HRA) 旨在标准化对健康成年人体的描述.
- 现有的数据缺乏标准化术语和空间引用,阻碍了跨度生物分析.
研究的目的:
- 引入人类参考图谱知识图 (HRA KG) 作为中央数据资源.
- 使用资源描述框架 (RDF) 图表和SPARQL. 方便跨规模的生物查询.
- 为HRA KG的构建和部署提供数据,代码和方法.
主要方法:
- 开发了HRA KG,将解剖结构 (ASs),细胞类型 (CTs) 和生物标志物 (Bs) 与空间信息相结合.
- 使用了共同坐标框架本体学来标准化13种类型的数字对象 (DO).
- 部署了HRA KG作为链接开放数据,可以通过API和用户界面访问.
主要成果:
- HRA KG v2.2 (2025年5月) 涵盖了71个器官,5,800个AS,2,268个CT和2,531个BS.
- 该KG包含超过1000万个节点和1.71亿个边缘,大小为125.84 GB.
- 对于KG的构建和部署的数据和代码是公开的.
结论:
- HRA KG 作为标准化,跨度生物数据集成的基础资源.
- 基基支持人类生物学研究的高级查询和数据探索.
- 这项工作有助于为人体开发全面的数字地图集.
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