遗传证据表明,甲状腺功能与潜在的记忆和痴呆以及帕金森病相关的因果关系
Yang Wang1,2, Yanying Liu1,2, Huimin Yang1,2
1Shanxi Key Laboratory of Big Data for Clinical Decision, Shanxi Medical University, Taiyuan, 030000, China.
Scientific reports
|July 1, 2025
概括
甲状腺刺激激素 (TSH) 能预防帕金森病 (PD),甲状腺功能低下能预防阿尔茨海默病 (AD) 和莱维体痴呆症 (DLB). 甲状腺功能低下症和甲状腺功能过高症 (HT) 可能会影响潜在记忆 (PM).
科学领域:
- 神经科学和内分泌学
- 遗传流行病学遗传流行病学
背景情况:
- 流行病学研究表明甲状腺功能与前性记忆 (PM) 之间存在联系,需要进一步调查.
- 了解甲状腺疾病和神经疾病之间的因果关系对于公共卫生至关重要.
研究的目的:
- 使用孟德尔随机化研究甲状腺功能标记物与前性记忆 (PM),帕金森病 (PD) 和痴呆症亚型之间的潜在因果关系.
- 探索甲状腺癌 (TC),甲状腺刺激激素 (TSH),甲状腺功能低下症,甲状腺功能增强症 (HT),辐射 (RAD) 和神经结果之间的遗传联系.
主要方法:
- 采用了两个样本的门德尔随机化 (MR) 研究设计.
- 全基因组关联研究 (GWAS) 的数据被用于暴露 (TC,TSH,甲状腺功能低下,HT,RAD) 和结果 (PM,PD,阿尔茨海默病 (AD),莱维体痴呆症 (DLB),前性痴呆症 (FTD),血管痴呆症 (VD)).
- 反变量加权 (IVW) 方法是主要的分析方法,并补充了异质性和灵敏性分析.
主要成果:
- 甲状腺刺激激素 (TSH) 显示出对帕金森病 (PD) 的因果保护作用 [OR=0.811,p=0.010].
- 甲状腺功能低下与阿尔茨海默病 (AD) [OR=0.954,p=0.022]和莱维体痴呆症 (DLB) [OR=0.845,p=0.009]的风险降低有因果关系.
- 潜在的甲状腺功能低下症和PD/PM之间以及甲状腺功能过高症 (HT) 和PM之间存在潜在的因果关系,尽管TSH,甲状腺功能低下症和HT与痴呆症亚型没有显示因果关系.
结论:
- TSH作为PD的保护因素,以及AD和DLB的甲状腺功能低下症.
- 甲状腺功能低下症可能会增加潜在记忆 (PM) 缺陷和PD的风险,而HT可能是PM的风险因素.
- 甲状腺癌 (TC) 和辐射 (RAD) 并没有证明与PM,PD或痴呆风险的因果关系.
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