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拉米娜·克里布罗萨 (Lamina cribrosa) 的曲率深度和指数是格雷夫斯眼科病的新参数

Abdullah Ergen¹, Büşra Yılmaz Tuğan²

¹Department of Ophthalmology, Kocaeli University, Kocaeli, Turkey.

Scientific reports

|July 1, 2025

概括

格雷夫斯眼病 (GO) 改变了状膜 (LC) 形态,观察到LC厚度 (LCT) 降低,曲率深度 (LCCD) 和曲率指数 (LCCI) 增加. 这些光谱域光学连贯性断层扫描 (SD-OCT) 发现有助于区分GO患者与健康个体.

科学领域:

眼科医生眼科眼科
医疗成像医学成像
内分泌学在内分泌学.

背景情况:

格雷夫斯眼病 (GO) 是一种影响眼睛的自身免疫性疾病,可能导致视力受损.
视神经头部的关键结构 - - 视膜 (LC) 可能会在GO患者中发生形态变化.
光谱域光连贯性断层扫描 (SD-OCT) 是评估眼睛结构的宝贵工具.

研究的目的:

在使用SD-OCT的Graves'眼病 (GO) 患者中,研究状膜 (LC) 参数,黄斑质细胞层厚度 (GCLT) 和周周视网膜神经纤维层厚度 (RNFLT).
为了比较GO患者和健康对照之间的这些参数.
为了确定LC形态学在GO的诊断价值.

主要方法:

包括70名GO患者和70名健康对照.
SD-OCT用于测量LC厚度 (LCT),LC深度 (LCD),LC曲率深度 (LCCD),LC曲率指数 (LCCI),周围毛囊RNFLT和黄斑GCLT.
此外,还评估了proptosis和临床活性评分 (CAS).

主要成果:

在GO患者和对照人群之间发现了LC形态的显著差异.
与对照组 (276.1 ± 36.3 μm) 相比,LCT在GO患者 (236.7 ± 37.1 μm) 中显著下降 (p < 0.001).
在GO组中,LCCD和LCCI显著更高 (p < 0.001).
在LCD,黄斑GCLT或周周毛囊RNFLT中没有发现显著差异.

结论:

在患有格雷夫斯眼科病的患者中,Lamina cribrosa形态发生了变化.
LCT,LCCI和LCCD是将GO与健康对照区分开来的有效参数.
这些LC参数可以作为GO的辅助诊断工具.

关键词:

团结细胞层是团结细胞层.格雷夫斯的眼病是眼科病.拉米娜·克里布罗萨 (Lamina cribrosa) 的曲率深度和曲率深度.拉米娜·克里布罗萨的曲率指数拉米娜·克里布罗萨的厚度

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